معرفی
Mark Crabtree is a University Research Lecturer and British Heart Foundation Intermediate Basic Science Research Fellow at the University of Oxford, leading the Channon Group focused on cardiovascular functional genomics and redox signaling. His research integrates metabolomic and proteomic approaches to study nitric oxide mechanisms in cardiovascular disease models.
Education: BSc (Hons) from the University of Surrey (2001), followed by a collaborative PhD at the University of Surrey and Weill Medical College of Cornell University. Postdoctoral training under Professor Keith Channon began in 2006, supported by a BHF Centre of Research Excellence Transition Fellowship (2012–2015).
Research interests include nitric oxide delivery systems for cardiovascular therapies, redox signaling in cardiac injury, and tetrahydrobiopterin's role in metabolic regulation. His work bridges nanomaterials development (e.g., graphene-based NO-releasing coatings) with clinical applications in ischemia-reperfusion injury and atherosclerosis.
Notable contributions include advancements in pH-sensitive NO delivery systems and mechanistic insights into myocardial nitroso-redox imbalance post-cardiac surgery. He chairs the 2018 International Nitric Oxide Society Conference and serves on the society's council.
Scientific awards: British Heart Foundation Intermediate Basic Science Research Fellowship. Active grants include BHF funding for redox signaling studies. His lab collaborates internationally, with recent publications spanning NO-based therapies, metabolic reprogramming in macrophages, and vascular biology.
