Jawahar Mehta

Jawahar Mehta is a Distinguished Professor at the University of Arkansas for Medical Sciences, College of Medicine, Department of Internal Medicine (Cardiology Division). His research focuses on molecular mechanisms of cardiovascular diseases, particularly atherosclerosis, oxidized LDL receptors (LOX-1), PCSK9 interactions, ischemia-reperfusion injury, and cardiovascular implications of COVID-19. He directs translational studies spanning drug design, cellular senescence, and inflammatory pathways.

Research interests center on:

• LOX-1 receptor biology: Structure-function relationships in atherosclerosis
• PCSK9 signaling: Roles beyond cholesterol metabolism
• Ischemia-reperfusion injury: Molecular pathways and therapeutic targets
• Cardiometabolic interfaces: Renal biomarkers in heart failure, diabetes-cardiovascular interactions
• Emerging technologies: AI applications in cardiovascular diagnostics

His recent publications demonstrate strong focus on:

• Molecular regulators of vascular senescence (PCSK9, LOX-1)
• COVID-19 interactions with lipid metabolism and cardiac injury
• Machine learning applications in heart failure management
• Novel therapeutic targets in atherosclerosis and ischemia-reperfusion

Research funding includes principal investigator roles for:

• NIH/NHLBI-funded TOPCAT trial (heart failure with preserved ejection fraction)
• American Heart Association grants on LOX-1 targeted drug design
• Industry collaborations on FAP inhibitors and pioglitazone mechanisms