Marco H. Siderius

Marco H. Siderius serves as an Associate Professor at Vrije Universiteit Amsterdam (VU Amsterdam) within the Faculty of Science, Department of Chemistry and Pharmaceutical Sciences, and is affiliated with the AIMMS research institute. His academic career spans both fundamental biochemical research and translational pharmacological applications.

Dr. Siderius' research primarily focuses on G protein-coupled receptors (GPCRs), with particular expertise in CXCR4 signaling pathways and their implications in cancer biology and viral pathogenesis. His work explores receptor oligomerization, nanobody-based targeting strategies, and the role of viral chemokine receptors in disease mechanisms. The research fingerprint reveals strong connections to Chemokine Receptor (100%), G Protein Coupled Receptor (86%), Human Cytomegalovirus (81%), and Phosphodiesterase (73%) research areas.

Analysis of recent publications shows a clear trend toward therapeutic applications of GPCR research, particularly in oncology. His work bridges molecular pharmacology with cancer therapeutics, examining how receptor modulation affects tumor progression and treatment resistance. Key themes include CXCR4 oligomerization in lymphoid neoplasms, development of novel inverse agonists like TG-0054, and innovative nanobody approaches for receptor targeting.

Dr. Siderius actively contributes to academic training through multiple courses including Cellular Biochemistry and Molecular Pharmacology. His teaching schedule extends to the 2025-2026 academic year, indicating ongoing faculty engagement. Though specific awards aren't listed in the provided materials, his research output of 63 publications including high-impact papers in PNAS demonstrates significant scholarly contribution.

In terms of academic mentoring, Dr. Siderius has supervised 13 PhD theses, reflecting his commitment to training the next generation of scientists. His research spans from fundamental yeast stress response mechanisms (evident in early 2001 activities) to current cutting-edge work on chemokine receptors and cancer biology. The collaborative nature of his work is evident through extensive co-authorship patterns across multiple institutions.