HF Vischer

Dr. HF Vischer is an Assistant Professor at the Faculty of Science of Vrije Universiteit Amsterdam, specifically in the Department of Chemistry and Pharmaceutical Sciences, with a secondary appointment at AIMMS (Amsterdam Institute for Molecules, Medicines and Systems). His research focuses on G protein-coupled receptors (GPCRs), particularly histamine receptors (H1, H3, H4) and chemokine receptors, exploring their pharmacology, ligand design, and photopharmacology. He investigates signaling pathways, ligand-receptor interactions, and optogenetic tools for real-time receptor modulation.

Key areas include developing photoswitchable ligands, studying receptor isoforms, and applying technologies such as NanoBRET for real-time pharmacology. His work spans drug design, molecular mechanisms of receptor activation, and translational applications in medicine. He has supervised 6 PhD theses and maintains collaborations in medicinal chemistry, structural biology, and systems pharmacology.

Publications emphasize ligand synthesis, receptor pharmacology, and optical control strategies, with contributions to journals like Journal of Medicinal Chemistry and Nature Communications. His research addresses drug discovery challenges, targeting inflammatory, neurological, and cardiovascular disorders.