معرفی
Dr. Marc-André Langlois is a Full Professor in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa's Faculty of Medicine. He serves as Executive Director of the national Coronavirus Variants Rapid Response Network (CoVaRR-Net) and holds the Faculty of Medicine Chair of Excellence in Pandemic Viruses and Preparedness Research. An expert in molecular virology and intrinsic immunity, his work bridges retrovirology (e.g., HIV) and respiratory virus research (e.g., SARS-CoV-2, influenza), with a focus on host-virus interactions.
- Executive Director, CoVaRR-Net
- Faculty of Medicine Chair of Excellence, Pandemic Viruses
- Canada Research Chair in Molecular Virology and Intrinsic Immunity
- Member, Royal Society of Canada (College)
Research interests center on:
- Host Intrinsic Immunity: Mechanisms of APOBEC3 proteins in restricting retroviruses like HIV
- Viral Latency: Role of APOBEC3 mutagenesis in HIV persistence
- Respiratory Virus Serology: High-throughput antibody assays for SARS-CoV-2 and seasonal coronaviruses
- Mucosal Immunity: Systemic and mucosal responses to vaccines, including intranasal candidates
Recent publications highlight expertise in:
- Immune imprinting in antigenic variation
- Cross-neutralization of SARS-CoV-2 via seasonal coronavirus antibodies
- HIV integration site profiling by APOBEC3 enzymes
- Development of scalable serology platforms
- Mucosal vaccine characterization
Scientific awards include:
- Canada Research Chair in Molecular Virology and Intrinsic Immunity
- Faculty of Medicine Chair of Excellence
- Member, Royal Society of Canada (College)
His Serology and Diagnostics High Throughput Facility executed over 2 million assays during the pandemic, supporting 40+ national studies including Statistics Canada's seroprevalence surveys. Research informs federal decision-making through Health Canada and CIHR collaborations.
