معرفی
Dr. Manuel Collado Rodríguez is a researcher at the University of Santiago de Compostela (USC), leading the ColladoLab within the Center for Research in Molecular Medicine and Chronic Diseases (CIMUS). He holds a PhD from the Autonomous University of Madrid (1997), focusing on HIV-1 immunology under Dr. Mariano Esteban Rodríguez. His research centers on cellular senescence's role in cancer and aging, with particular emphasis on tumor suppression mechanisms, epigenetic regulation, and senescence-associated secretory phenotypes. His lab investigates these processes through in vivo models and explores therapeutic applications such as senolytic compounds and cellular reprogramming. Collaborations include institutions like i3S in Porto, Portugal, and involvement in international conferences like the Wiggers-Bernard Conference on Cellular Senescence.
Research Focus: His work spans molecular mechanisms of senescence, oncogene-induced senescence, and the interplay between senescence and cancer progression. Key areas include SOX2 regulation in cancer, p53 signaling pathways, and extracellular vesicle biology. His lab also engages in translational research, such as evaluating diet's impact on tumor microenvironments and exploring CRISPR-Cas13d for antiviral therapies.
Publications Trends: Recent articles emphasize guidelines for senescence experimentation, epigenetic reprogramming in tumors, and senescence's dual role in cancer control and promotion. His work bridges basic science and clinical applications, addressing aging-related diseases and cancer therapies.
Lab Activities: The ColladoLab hosts students and researchers, with ongoing projects funded by GAIN-Xunta de Galicia and other initiatives. Projects include studying senescence in zebrafish models, senotherapies for cancer, and investigating senescence biomarkers in clinical settings.
