معرفی
Han Li is a permanent researcher and structural leader at the Institut Pasteur in Paris, affiliated with the team Membrane, Cytosquelette et Division Cellulaire under the Department of Cell Biology and Infection. Han Li leads research projects focused on cellular plasticity in aging and cancer, exploring mechanisms of cellular reprogramming, senescence, and regeneration.
Research Interests:
- Cellular reprogramming and stem cell biology
- Mechanisms of aging and cellular senescence
- Aberrant plasticity in cancer development
- In vivo models of tissue regeneration
- Gene regulation in pluripotency (e.g., Sox2)
The recent publications highlight work in in vivo reprogramming, particularly in skeletal muscle, using mouse models to study how injury-induced senescence can be leveraged for regenerative purposes. The research bridges fundamental cell biology with implications for regenerative medicine and oncology.
Scientific Contributions:
- Pioneering studies on injury-induced senescence enabling reprogramming
- Development of assays for detecting senescence during reprogramming
- Exploration of p27 and Sox2 in dysplastic cell states
Han Li supervises PhD students and postdoctoral researchers, contributing to training the next generation of scientists in cell and developmental biology. The work is supported by institutional funding and collaborative initiatives at Institut Pasteur, including LabEx Revive in regenerative biology.
Laboratory and Team: The research is conducted within a dynamic team studying cell division, cytoskeleton, and cellular identity, with access to advanced core facilities including organ-on-chip and animal models.
