معرفی
Makaia Papasergi, Ph.D., is an Assistant Professor in the Department of Biochemistry and Biophysics at the University of Rochester Medical Center, affiliated with the School of Medicine and Dentistry. The Papasergi-Scott Lab investigates molecular mechanisms and spatiotemporal dynamics of G protein signaling pathways using cryo-electron microscopy (cryo-EM) integrated with biochemical, cellular, and pharmacologic approaches.
- Principal Investigator, Papasergi-Scott Lab
- Affiliated with Ph.D. programs in Biophysics, Structural & Computational Biology; Biochemistry & Molecular Biology; and Cellular and Molecular Pharmacology and Physiology
Research focuses on structural and functional analysis of G protein-coupled receptors (GPCRs), G proteins, and downstream effectors within signaling complexes. Key areas include cryo-EM studies of GPCR dynamics, G protein activation, and membrane protein interactions.
Recent publications highlight structural insights into GPCR-G protein coupling, allosteric modulation of calcium receptors, and chaperone mechanisms for G protein folding. The lab's work aims to identify novel therapeutic targets by elucidating disrupted G protein signaling in disease.
The Papasergi-Scott Lab team includes Principal Investigator Makaia Papasergi, Research Technician William Richardson, and graduate students Samuel Hunt, Wesley Mounts, and Melina Pinzon. The lab is located at Office 4-6718, 601 Elmwood Ave, Rochester, NY 14642.
