معرفی
Lia Paim serves as an Adjunct Professor in the Department of Veterinary Biomedicine at the University of Montreal's Faculty of Veterinary Medicine. Her research focuses on microtubule dynamics in cellular processes critical to reproduction and development. She maintains active laboratory operations at the Pavillon 3200, rue Sicotte (Aile B, local 2980) and holds dual affiliations with the Centre de recherche en reproduction et fertilité (CRRF) and Centre d’expertise et de recherche clinique en santé et bien être animal (CERCL).
Her educational background includes:
- B.Sc. in Biomedicine from Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil
- M.Sc. in Health Sciences from Universidade Federal de Ciências da Saúde de Porto Alegre, Brazil (thesis: Development of a protocol for rat oocyte cryopreservation)
- Ph.D. in Biomedical Sciences from Université de Montréal, Canada (thesis: Cytokinesis in the mouse preimplantation embryo: mechanism and consequence of failure)
- Postdoctoral training in Cell Biology at McGill University, Canada (research: Regulation of microtubule dynamics by microtubule-associated proteins)
Dr. Paim's research investigates how microtubule-associated proteins (MAPs) and tubulin post-translational modifications regulate cytoskeletal dynamics in somatic cells, oocytes, and embryos. Her laboratory employs genetics, live-cell microscopy, immunofluorescence, and proteomics to explore connections between microtubule dysfunction and pathologies including cancer, developmental disorders, and infertility. A significant focus examines how assisted reproductive techniques like cryopreservation affect microtubule integrity and how protocol modifications can mitigate these impacts. Current projects include studying microtubule acetylation in mouse embryos, regulation of spindle microtubule subpopulations, and cellular impacts of egg cryopreservation.
Her publication record demonstrates consistent output in high-impact journals including PNAS, Nature Communications, and Cell Cycle, with research themes centering on chromosomal instability, cytokinesis mechanisms, and cytoskeletal regulation in developmental contexts. Recent work increasingly integrates proteomics with live-cell imaging to uncover molecular mechanisms.
Scientific recognition includes:
- NSERC Postdoctoral Fellowship (2022-2024)
- FRQS Doctoral Scholarship (2018-2021)
- Multiple travel awards from Canadian research societies (CRRF, SRF)
- Five best presentation awards at national conferences (2020-2023)
- CRCHUM Excellence Award for high-impact publication (2020)
Dr. Paim actively recruits Master's students for projects involving embryo culture, micromanipulation, and advanced microscopy. Her laboratory provides scholarship support and emphasizes training in developmental biology, cell biology, and high-resolution imaging techniques. She maintains professional memberships in the Canadian Fertility and Andrology Society and Society for the Study of Reproduction, contributing to national reproductive science networks.
