معرفی
Leslie Benet is a Professor in the Departments of Bioengineering and Therapeutic Sciences and Pharmaceutical Chemistry at the University of California San Francisco (UCSF). With a career spanning over five decades, he has made foundational contributions to pharmacokinetics, biopharmaceutics, and drug disposition. His work includes co-founding the Journal of Pharmacokinetics and Biopharmaceutics (1973–1998) and developing the Biopharmaceutics Drug Disposition Classification System (BDDCS).
- PhD in Pharmaceutical Chemistry, University of California San Francisco
- MS in Pharmaceutical Chemistry, University of Michigan
- BS in Pharmacy, University of Michigan
- BA in English, University of Michigan
Research interests focus on pharmacokinetics, drug metabolism, transporter-enzyme interplay, in vitro-in vivo extrapolation (IVIVE), and biopharmaceutics. His recent work critiques traditional hepatic clearance models and emphasizes the utility of Kirchhoff's Laws in pharmacologic analyses. He has over 620 publications and 12 patents.
Publications reveal expertise in hepatic clearance prediction, transporter biology (P-gp, BCRP), metabolic drug interactions, and BDDCS applications. His studies often bridge theoretical pharmacokinetics with clinical translation.
- Major awards: Remington Medal (2016), Frankfurt Foundation Lifetime Achievement (2023), nine honorary doctorates, NAM membership (1987), AAPS Distinguished Scientist (1989)
- Leadership roles: Founder of UCSF's drug development course, Chair of NIH Pharmacology Study Section, President of AAPS (1986), and current Chair of Medicines360's Board
