معرفی
Nina Isoherranen is a Professor and Milo Gibaldi Endowed Chair in the Department of Pharmaceutics at the University of Washington School of Pharmacy. She holds multiple affiliations including the Drug Design/Metabolism/Transport and Research and Training Consortium (DMTSPR), Pharmaceutics Faculty, School Faculty, and the Program on Pharmacokinetics of Drugs of Abuse during Pregnancy (UWPKDAP).
Her educational background includes:
- PhD in Pharmaceutical Sciences from the Hebrew University of Jerusalem (2003)
- Master of Science in Analytical Chemistry
- Bachelor of Science in Chemistry from the University of Helsinki, Finland (1998)
Dr. Isoherranen's research program focuses on the metabolism, disposition, and biological effects of Vitamin A and Retinoic acid, drug disposition and safety during pregnancy, and pharmacokinetic modeling of drug-drug interactions. Her work includes studies on the role of CYP26 and ALDH1A enzymes in Vitamin A homeostasis, alterations in vitamin A metabolome in obesity and related comorbidities, and how drug and vitamin metabolism change during pregnancy. She actively develops physiologically based pharmacokinetic (PBPK) models to predict complex drug-drug and disease-drug interactions, as well as clearance changes in different physiological states. Her research has significant implications for understanding drug safety in special populations, particularly pregnant women and individuals with metabolic disorders.
Analysis of her recent publications reveals a strong emphasis on pharmacokinetics, drug metabolism, and translational pharmacology. Her work spans from fundamental biochemical studies of enzyme systems to clinical applications, with particular emphasis on pregnancy pharmacology, vitamin metabolism, and advanced modeling approaches. The breadth of her research demonstrates expertise across multiple disciplines including pharmaceutical sciences, biochemistry, and clinical pharmacology.
Dr. Isoherranen is actively mentoring students in her laboratory and continues to develop innovative approaches to understanding drug disposition in special populations. She teaches courses PCEUT532, PCEUT506, and PCEUT502 in the Pharmaceutics program.
Her laboratory is part of the Drug Design/Metabolism/Transport and Research and Training Consortium (DMTSPR) at the University of Washington, which focuses on advancing understanding of drug metabolism, transport mechanisms, and their implications for drug development and clinical use.
