Daniel Scotcher

Daniel Scotcher is a Lecturer in Applied Pharmacokinetics and PBPK/IVIVE Lead at the Centre for Applied Pharmacokinetic Research (CAPKR). He specializes in developing computational models to predict drug metabolism and transport in vivo, particularly focusing on physiologically-based pharmacokinetic (PBPK) frameworks for in vitro-in vivo extrapolation (IVIVE). His research emphasizes renal drug disposition, the impact of chronic conditions like chronic kidney disease (CKD), and the application of PBPK models for non-CYP enzymes such as aldehyde oxidase. He holds editorial board roles for Drug Metabolism and Disposition and leads educational units on PBPK modeling within the MSc in Model-Based Drug Development.

His research interests include drug transporter modulation (OAT1/OAT3, OCT2), endogenous biomarkers for transporter activity, and the translation of experimental data into clinical outcomes. He has collaborated internationally with pharmaceutical companies and clinicians, advancing understanding of creatinine-drug interactions and renal dysfunction effects. His work contributes to UN Sustainable Development Goals related to health and innovation.

• PhD in Pharmacokinetics (2016)
• Supervised by Prof. Anika Rostami-Hodjegan and Prof. Andrey Galetin

Key contributions include PBPK modeling of renal drug disposition, albumin-mediated drug uptake mechanisms, and biomarker-informed DDI evaluation. His collaborative projects address CKD-induced pharmacokinetic changes and drug interaction risks in special populations.