معرفی
Leslie B. Poole serves as Professor in the Department of Biochemistry at Wake Forest School of Medicine, Wake Forest University, where she has been faculty since 1992. She holds leadership roles as Director of the Center for Structural Biology and Co-Director of the Center for Redox Biology & Medicine, contributing significantly to institutional research infrastructure and scientific community engagement.
Her educational background includes:
- B.A. in Biology & Chemistry, Wake Forest University (1980)
- Ph.D. in Biochemistry, Wake Forest University (1988)
- Postdoctoral Fellowship, University of Maryland-College Park (1988-1991)
Dr. Poole is an internationally recognized expert in redox biology, specializing in oxidation/reduction control of protein and enzyme function. Her pioneering work defined the chemistry of biological thiol redox reactions and established hydrogen peroxide as a critical signaling molecule. Her research bridges biochemistry, cancer biology, and translational medicine, with applications in developing novel therapeutics and diagnostic tools for oxidative stress-related diseases. Current investigations focus on redox regulation in cancer progression, cardiotoxicity of chemotherapeutics, and mitochondrial oxidative stress mechanisms.
Analysis of her recent publications (2022-2025) reveals persistent emphasis on peroxiredoxin function, protein sulfenylation detection, and redox-mediated signaling in cancer and inflammation. Key trends include therapeutic targeting of redox vulnerabilities in KRAS-mutant cancers, mitochondrial redox control of immune responses, and innovative approaches to mitigate chemotherapy-induced cardiotoxicity through redox modulation.
Her scientific recognition includes:
- 2024 WFU Friends of Chemistry Distinguished Alumni Award
Dr. Poole has secured over $16 million in extramural funding (94% from NIH), demonstrating exceptional grant-writing success. She has mentored numerous graduate students and postdoctoral fellows while leading collaborative research initiatives. Her administrative contributions span university committees including safety oversight and Women in Medicine & Science advocacy.
She directs the Center for Structural Biology and co-directs the Center for Redox Biology & Medicine, where her team develops redox-based detection technologies including the patented platform commercialized through Xoder Tech, LLC, a Women Owned Small Business she co-founded.
