معرفی
Roles & Affiliations: Bruce King is the Thurman D. Kitchin Professor of Chemistry at Wake Forest University. He leads a research group focusing on redox biochemistry and collaborates with interdisciplinary teams across chemistry, physics, and medicine.
Education:
- BS and MS in Chemistry, West Virginia University
- PhD in Chemistry, Cornell University
- Postdoctoral Research, The Scripps Research Institute
Research Interests: The King lab investigates small molecule interactions in redox biochemistry, particularly the roles of nitric oxide (NO), hydrogen sulfide (H2S), and nitroxyl (HNO) in bacterial metabolism. Key projects include:
- Reactivity of nitroxyl with bacterial thiols (bacillithiol/mycothiol)
- Total synthesis of thiols for antibiotic development
- Development of HNO detection methods
Publications Trends: Recent work emphasizes nitroxyl's role in bacterial sulfur metabolism and mitochondrial protein oxidation, with applications in imaging (e.g., [18F]Fluoro-DCP) and vaccine design (R848 adjuvanted influenza).
Awards:
- MacDonough Family Faculty Fellowship
- American Heart Association Established Investigator
- Henry Dreyfus Teacher-Scholar
Grants & Labs: Active in NIH-funded research and collaborates with Wake Forest's medical school. The lab trains students in organic synthesis, biophysical techniques, and molecular biology. No explicit grants listed, but publications indicate sustained NIH support.
Teams: Collaborations include groups in protein oxidation (Poole/Furdui), imaging (Tsang), and vaccine development (Alexander-Miller).
