معرفی
Lawrence Sinoway, MD, is Distinguished Professor of Medicine in the Division of Cardiology at Pennsylvania State University College of Medicine, and a leading investigator within the Penn State Clinical and Translational Science Institute (CTSI) and Penn State Heart and Vascular Institute. Over a career spanning nearly five decades, he has produced 240 research outputs, secured 47 major NIH grants, and achieved an h-index of 55 with >9,000 citations.
Education & Training:
While the provided text does not enumerate his degrees, Dr Sinoway’s title of “MD” indicates medical training; additional academic credentials are likely but are not explicitly stated.
Research Focus:
Dr Sinoway’s work centres on cardiovascular autonomic control, with particular emphasis on muscle sympathetic nerve activity, baroreflex and chemoreflex regulation, exercise pressor reflex mechanisms, and peripheral arterial disease. His investigations range from cellular signalling to whole-human integrative physiology, leveraging translational approaches that align with the goals of the Penn State CTSI.
Recent publications (2023-2025) demonstrate sustained productivity in:
- Pharmacologic optimisation of heart failure therapy (e.g., sacubitril/valsartan dosing)
- Mechanisms of autonomic dysfunction in peripheral arterial disease, heart failure with preserved ejection fraction, and diabetes mellitus
- Novel device-based haemodynamic modulation (e.g., HeartWare LVAD speed adjustment during exercise)
- Non-pharmacological interventions such as inspiratory muscle training and dietary nitrate supplementation
Honours & Awards:
- Career Research Excellence Award – Penn State University (2017)
Research Funding & Leadership:
Dr Sinoway has served as Principal Investigator or Co-Investigator on 47 funded projects. Ongoing NIH support includes:
- Penn State CTSI (NCATS) – Co-PI (2016-2026)
- “The Human Cardiovascular Control: The Role of Limb Veins” – NHLBI Co-PI (2019-2024)
- Program Project “Acute and Chronic Afferent Engagement” – NHLBI PI/Co-PI (2017-2022)
Laboratory & Teams:
Dr Sinoway directs active research teams embedded within the Penn State Heart and Vascular Institute and the Clinical Research Center. His group employs state-of-the-art microneurography, Doppler ultrasound, and metabolic techniques to dissect autonomic mechanisms in health and disease.
