معرفی
Katja Gehmlich serves as a Visiting Scientist and British Heart Foundation Intermediate Basic Science Research Fellow at the University of Oxford's Division of Cardiovascular Medicine. Her research focuses on molecular mechanisms underlying cardiomyopathies, particularly biomechanical stress signalling in hypertrophic cardiomyopathy (HCM).
Her primary research interests include:
- Biomechanical stress pathways in cardiac tissue
- Metabolic reprogramming in genetically modified cardiomyocytes
- Genetic variants affecting sarcomere proteins (ACTN2, MuRF1, Filamin C)
- Atrial electrophysiological remodeling in metabolic disorders
Recent publications reveal converging themes across cardiac biomechanics, protein homeostasis, and metabolic adaptation. Her work integrates induced pluripotent stem cell models, transgenic mouse systems, and structural biology to dissect disease mechanisms in HCM and Fabry disease.
Key recognition:
- British Heart Foundation Intermediate Basic Science Research Fellowship
Dr. Gehmlich leads the Gehmlich group focused on 'Biomechanical stress signalling in the heart and its role in cardiomyopathies,' investigating how mechanical forces translate into pathological signalling through sarcomeric proteins and chaperone systems. Current projects examine HSPB7-Filamin C interactions, MuRF1 ubiquitylation defects, and stiffness-dependent metabolic shifts in engineered cardiac tissues.
