معرفی
Jürg Müller is a Researcher at the Max Planck Institute for Biochemistry, leading the Chromatin Biology group. His work focuses on the biochemical mechanisms of chromatin-modifying enzymes and their role in gene transcription regulation.
- Research Overview: Investigates Polycomb/trithorax group proteins, histone modifications, and chromatin structure in Drosophila development.
- Key Techniques: Integrates biochemistry, structural biology, genetics, and genomics.
Research Interests:
- Chromatin structure and function
- Propagation of repressed chromatin states
- Structural analysis of chromatin-modifying complexes
- Role of histone ubiquitination/deubiquitination
- Epigenetic regulation in development and disease
- Mechanistic analysis of Polycomb/trithorax systems
Scientific Trends: Recent publications analyze histone modification crosstalk, PRC2/PRC1 complex dynamics, and stoichiometric relationships in chromatin regulation. Structural insights reveal molecular mechanisms of nucleosome recognition and enzymatic activation.
Team Members: Collaborations include postdocs (Jacques Bonnet, Deepali Bobade), PhD students (Maria Ciapponi, Beyza Dedeoglu), Master students (Berfin Yesil), and research assistants (Petra Lee, Ulrike Goldschmitt).
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