معرفی
Justin Bosch is an Assistant Professor of Human Genetics at the University of Utah, specializing in inter-organ communication via circulating proteins and hormones. His lab employs advanced experimental and computational tools such as TurboID proximity labeling, CRISPR genome engineering, mass spectrometry, and AI-driven protein interaction modeling to unravel systemic signaling networks in Drosophila and human systems.
- B.S., University of Wisconsin–Madison
- Ph.D., University of California, Berkeley
Research focuses on:
- Mapping tissue-specific origins and destinations of blood proteins using proximity labeling enzymes
- Developing AI-powered pipelines for hormone-receptor interaction discovery
- Characterizing novel inter-organ factors regulating body size and synaptic strength
- Advancing CRISPR-based tools for precise genome modifications in Drosophila
- Elucidating molecular mechanisms of hormone-receptor binding specificity
Publications highlight his interdisciplinary approach combining proteomics, computational biology, and Drosophila genetics to address fundamental questions in inter-organ communication. Key methodologies include TurboID for secretome mapping, GPU-accelerated AlphaFold interaction screens, and modular vector assembly for CRISPR applications.
His lab actively recruits researchers for high-risk/high-reward projects, particularly postdocs for computational pipeline development and graduate students for factor characterization. Collaborative work spans institutions including Harvard Medical School and Broad Institute, with affiliations to the University of Utah Center for High Performance Computing.
