معرفی
Justin A. Bosch is an Assistant Professor in the Department of Human Genetics at the University of Utah. His research focuses on inter-organ communication through blood-borne proteins, primarily using Drosophila as a model system with human-like organ systems. The Bosch Lab employs a multidisciplinary approach combining experimental and computational techniques to map protein origins and destinations in circulation.
Research interests center on discovering novel circulating inter-organ factors that mediate communication between organ systems. Key areas include hormone signaling, protein trafficking mechanisms, and the functional characterization of blood proteomes. The lab develops innovative tools such as protein proximity labeling (TurboID), computational prediction of protein complexes (AlphaFold), and CRISPR-based genome engineering to overcome technical barriers in studying inter-organ communication.
Analysis of recent publications reveals a strong focus on Drosophila genetics, proteomics, and CRISPR technologies. The research trajectory shows progression from foundational genetic tools development toward comprehensive mapping of inter-organ communication networks, with increasing integration of computational approaches and human disease relevance.
The Bosch Lab maintains active funding and collaborations, including recent support from the U of U Health Philanthropic Partners Group for high-risk, high-reward projects. The lab has established critical infrastructure including a GPU node at the Center for High Performance Computing and utilizes the Cell Imaging Core for advanced microscopy.
Current lab personnel include research technicians and undergraduate researchers working on projects related to characterizing candidate inter-organ factors, developing novel experimental tools, and investigating human missense variants in hormones and their receptors. The lab actively participates in academic symposia and retreats within the Department of Human Genetics and broader university community.
