معرفی
Jost Enninga is Head of Structure and leads the Research Unit 'Dynamics of Host-Pathogen Interactions' at the Institut Pasteur in Paris, France. His work focuses on deciphering the molecular and cellular mechanisms of bacterial invasion by pathogens such as Shigella and Salmonella, using advanced fluorescence microscopy and real-time single-cell imaging.
- Institution: Institut Pasteur
- Department: Dynamics of Host-Pathogen Interactions
- Email: jost.enninga@pasteur.fr
- Research Focus: Host-pathogen interactions, intracellular infection, bacterial invasion, autophagy, fluorescence microscopy
His research interests lie at the intersection of microbiology, cell biology, and quantitative imaging. He investigates how bacterial pathogens manipulate host cell processes during invasion, particularly focusing on vacuolar rupture, cytosolic escape, and intracellular niche formation. His lab employs cutting-edge techniques including live-cell imaging, cryo-electron tomography, and structured illumination microscopy to visualize infection dynamics in real time.
The recent publications of his team span high-impact journals such as PLoS Biology, Nature Communications, and Cell Reports, with recurring themes in bacterial secretion systems, host membrane dynamics, Rab GTPase manipulation, and actin subversion. These works reflect a strong trend toward mechanistic understanding of pathogen-host interactions using interdisciplinary approaches combining molecular biology, imaging, and proteomics.
Dr. Enninga has received significant research funding from the European Research Council (ERC), Agence Nationale pour la Recherche (ANR), European Union (Marie Curie, ERC), and the Fondation pour la Recherche Médicale (FRM), among others.
- ERC-2015-CoG EndoSubvert
- ANR 2015 AutoHostPath
- ANR-2015 StopBugEntry
- Fondation Schlumberger pour l’Education et la Recherche
- Fundação para a Ciência e Tecnologia (FCT)
He actively mentors PhD students and postdoctoral researchers, including Arthur Lensen, Simon Blachier, Keith Egger, and Margaux Bilay. He also contributes to academic training by co-organizing advanced microscopy courses at the Institut Pasteur, such as the 'Pasteur Course Principles and Applications of Fluorescence Microscopy.' His lab is part of broader transversal initiatives including the Quantitative Biology program and the Center for Vaccinology and Immunotherapy at the Institut Pasteur.
