معرفی
Olivier Disson is a permanent INSERM research scientist (“Chargé de Recherche 1”), working since 2008 in the G5 “Microorganismes et barrières de l’hôte” unit (INSERM U604) at the Institut Pasteur, Paris, France. He leads the ANR-funded project “Microbial translocation across the intestinal epithelium (Organolist)” and participates in several national and international consortia investigating how Listeria monocytogenes breaches host barriers.
Education:
- Ph.D., Molecular and Cellular Biology, University of Montpellier II, 2004
- DEA (Master) Biology & Health Sciences, University of Montpellier II, 2000
- Magistère Molecular & Cellular Biology, École Normale Supérieure, Lyon, 1999
Research interests revolve around the cellular and molecular mechanisms that enable the food-borne pathogen Listeria monocytogenes to cross intestinal, placental and blood-brain barriers. Using intestinal organoids, live imaging, genetically-modified mice and comparative genomics, his work has uncovered critical roles for PI3-kinase signaling, InlB-mediated immune evasion, and species-specific invasion proteins in listerial dissemination.
Recent publications (2021-2024) highlight emerging themes: differential stress responsiveness shapes virulence heterogeneity, bacterial inhibition of Fas-mediated cell death promotes neuroinvasion, and neonatal susceptibility to meningitis reflects immature barriers and microbiota. These studies integrate genomics, cell biology and in vivo infection models to illuminate both pathogen and host determinants of disease.
Labs & Teams: Disson works within the Institut Pasteur G5 unit headed by Prof. Marc Lecuit, where he co-supervises post-doctoral fellows, PhD students and engineers on projects funded by ANR, ERC and Swiss National Science Foundation.
