معرفی
Professor Joseph Boyle is a Professor of Chemical Systems Pathology at the National Heart and Lung Institute, Imperial College London, within the Faculty of Medicine. His research focuses on gene regulation in macrophages related to atherosclerosis, integrating systems biology, pharmacology, and clinical translation. He holds affiliations with the Immuno-Pathology Network, Vascular Science Network, and Vasculitis Centre. Trained as a histopathologist (FRCPath), he combines clinical expertise with laboratory research in vascular biology.
Education: BSc (Hons) Pharmacology (University of Glasgow, 1988), MBChB (Glasgow, 1991), PhD (University of Cambridge, 1997–2001). Professional milestones include histopathology training (1992–2001) and postdoctoral fellowships at Imperial College London.
Research interests emphasize protective gene regulation in macrophages, leveraging spatial transcriptomics and imaging technologies. His work spans drug development (e.g., metformin’s anti-atherosclerotic effects), enzyme-based probes (HO-1 detection), and immune responses in cardiovascular disease. Awards include the University of Glasgow Pharmacology Prize and FRCPath certification.
Key contributions include identifying roles of SMARCA4, ATF1, and AMPK in macrophage function, and developing molecular imaging tools for atherosclerosis. His lab explores translational applications of these findings in diagnostics and therapeutics.
