معرفی
Jordan L. Meier is a Senior Investigator at the National Cancer Institute (NCI), leading the Epigenetics and Metabolism Section in the Chemical Biology Laboratory. His research bridges chemical biology, epigenetics, and cancer metabolism, focusing on how metabolic states influence epigenetic signaling and developing chemical tools for cancer therapy and diagnostics.
- Education: B.S. in Chemistry from Creighton University (2004); Ph.D. in Chemistry from University of California-San Diego (2009); Postdoctoral work at California Institute of Technology under Peter B. Dervan.
Dr. Meier’s work highlights three key areas: (1) Metabolic regulation of epigenetic signaling, exploring how metabolites like Acyl-CoA cofactors modulate chromatin-modifying enzymes; (2) Non-enzymatic acylation mechanisms, such as using thioester reactivity to map lysine acetylation in cancer; and (3) Oncometabolite detection, including the development of fluorescent probes for fumarate and a public chemoproteomic database.
His publications span chemoproteomics, RNA modifications, and metabolic-epigenetic interactions, with applications in diagnostics and therapeutic development. Awards include an American Cancer Society Postdoctoral Fellowship.
- Students/Trainees: Xuemin Chen, Thu Chu, Shereen Howpay Manage, Richard Mitchell, Minervo Perez, Supuni Thalalla Gamage, Ying Xiong, McKenna Crawford, Jared A. Grooms, Manini Penikalapati, Joycelyn Williams.
- Alumni: David Montgomery, Rhushi Kulkarni, Jonathan Shrimp, Thomas Zengeya, Wilson Sinclair, Julie Garlick, Abbey Thorpe, Sarah Bergholtz, Chloe Briney, Jeff Lopez, Justin Thomas.
Email: jordan.meier@nih.gov.
