معرفی
Jordan L. Meier, Ph.D. is a Senior Investigator and Head of the Epigenetics and Metabolism Section at the Chemical Biology Laboratory within the Center for Cancer Research at the National Cancer Institute, National Institutes of Health. His research bridges chemical biology, cancer metabolism, and epigenetic regulation, focusing on how metabolic states influence genomic signaling through chromatin modifying enzymes.
Dr. Meier's educational background includes:
- Bachelor's degree in Chemistry from Creighton University (2004)
- Ph.D. in Chemistry from University of California-San Diego (2009), working under Professor Michael D. Burkart
- Postdoctoral training as an American Cancer Society fellow at California Institute of Technology with Professor Peter B. Dervan
His research interests center on the intersection of metabolism and epigenetics, particularly how metabolic perturbations influence epigenetic signaling. Dr. Meier's laboratory develops chemical approaches to investigate metabolic and epigenetic signaling pathways in cancer, with special focus on acetyl-CoA mediated acetylation mechanisms and oncometabolite-driven cancers. His work aims to discover biological mechanisms underlying oncometabolite-driven cancers, develop new cancer diagnostics, and identify small molecules that inhibit epigenetic modifications through metabolic disruption.
Analysis of Dr. Meier's publications reveals a consistent research trajectory exploring the chemical biology of metabolic-epigenetic crosstalk. His work spans from fundamental chemical probe development to cancer-relevant biological applications, with particular emphasis on acetylation-based signaling mechanisms, oncometabolite detection, and chemoproteomic mapping of metabolic enzyme targets. His research has significantly advanced understanding of how metabolites like fumarate and acyl-CoA derivatives regulate epigenetic processes in cancer.
Notable recognition includes:
- American Cancer Society postdoctoral fellowship
Dr. Meier actively mentors a diverse research team including postdoctoral fellows and postbaccalaureate researchers. His laboratory has developed innovative chemical tools and approaches that have enabled new avenues for understanding metabolic regulation of epigenetic processes. Current research includes development of the Fumarate Chemoproteomic Reactivity Database to enable community efforts in studying FH-regulated cysteines.
The Chemical Biology Laboratory fosters a collaborative environment with active participation in symposia and scientific meetings. Dr. Meier's team engages in both fundamental chemical biology research and translational applications, with a particular focus on developing new approaches for cancer therapy, diagnosis, and chemoprevention based on metabolic-epigenetic connections.
