معرفی
Ronen Marmorstein is the George W. Raiziss Professor and Vice-Chair of the Department of Biochemistry and Biophysics at the University of Pennsylvania, with affiliations to the Abramson Family Cancer Research Institute. His research integrates structural biology, biochemistry, and inhibitor design to address mechanisms of protein acetylation, chromatin regulation, and cancer metabolism.
Education:
- B.S. in Chemistry and Genetics, University of California, Davis (1984)
- Ph.D. and M.S. in Chemistry, University of Chicago (1989)
- Certificate in Mentoring Facilitator for Faculty, Perelman School of Medicine (2022)
Research Interests focus on three interconnected areas:
- Epigenetic Regulation: Structural and functional analysis of histone chaperones (e.g., HIRA, ASF1) and acetyltransferases (HATs, KATs) in chromatin assembly and DNA repair.
- Protein Acetylation: Mechanistic studies of N-terminal acetyltransferases (NATs) and lysine acetyltransferases (KATs), including their roles in neurodegenerative diseases and cancer.
- Cancer Signaling: Targeting oncogenic kinases (e.g., BRAF, PAK1) and HPV proteins (E6, E7) with small-molecule inhibitors for melanoma and epithelial cancer therapies.
Publication Trends highlight his lab's work on acetyl-CoA metabolism (ACLY, G6PD), chromatin dynamics (HIRA, NatB), and therapeutic design (structure-based inhibitors). Keywords span epigenetics, structural biology, and oncology, with subfields like histone substrate binding, MAPK signaling, and allosteric enzyme regulation.
Scientific Contributions include seminal work on HAT/KAT/NAT enzymology, HIRA complex assembly, and inhibitors for BRAF, S6K1, and HPV oncoproteins. His lab has trained numerous graduate students and postdocs in biochemical and structural techniques.
Labs and Collaborations involve partnerships with the Peter Adams Laboratory on HIRA complex structure-function studies and the Karen E. Wellen Laboratory on metabolic-epigenetic crosstalk. Current projects include cryo-EM analysis of fatty acid synthase and NMR sensor design for zinc homeostasis.
