معرفی
John Wagner is a Professor at Weill Cornell Medicine's Graduate School of Medical Sciences, where he also serves as Director of the Graduate Program in Neuroscience. His research is conducted through the Wagner Laboratory within the Feil Family Brain & Mind Research Institute.
His educational background includes a Ph.D. in virus assembly from Princeton University under Dr. Uli Laemmli, followed by an NRSA Neuroscience Fellowship at the University of California, San Francisco with Dr. Regis Kelly, where he developed methods for purifying synaptic vesicles and studying axonal transport. He subsequently held positions as Assistant and Associate Professor in the Department of Chemistry at Harvard Medical School and Dana Farber Cancer Institute, focusing on NGF and adenosine signaling.
Dr. Wagner's research centers on the intersection of nervous and immune systems, specifically how sensory nerves form synapses with antigen-presenting cells in the skin to release neurotransmitters (CGRP and epinephrine) that modulate immune responses from TH1 to TH2 profiles. His laboratory employs genetic approaches to study IL-6 signaling between antigen-presenting cells and T cells, while also investigating adenosine's role in antigen presentation. In collaboration with Dr. Lorraine Gudas and Dr. Xiao-Han Tang, he explores retinoids' therapeutic potential for Type 2 Diabetes, Fatty Liver Disease, and cardiovascular health.
His work bridges neurobiology, immunology, and metabolic disease research, with current projects examining IL-6 presentation to naive T cells, IL-6 expression regulation, and IL-6 receptor signaling mechanisms. Dr. Wagner maintains strong affiliations with the Neuroscience and Cell & Developmental Biology programs at Weill Cornell.
