معرفی
John A. Wagner is a Professor of Neuroscience at the Brain and Mind Research Institute, Weill Cornell Medical College, a position he has held since 2012. His research bridges neuroscience and immunology, focusing on neuropeptide-mediated regulation of immune responses in cutaneous and neural contexts.
- Ph.D. in Neuroscience, Princeton University (1975)
- B.S., Loras College (1970)
Dr. Wagner's work centers on neuroimmune communication, particularly how calcitonin gene-related peptide (CGRP), pituitary adenylate cyclase-activating peptide (PACAP), and vasoactive intestinal peptide (VIP) modulate T cell differentiation, antigen presentation, and inflammatory pathways. His research demonstrates that neuropeptides critically bias immune responses toward Th17 lineages through endothelial and dendritic cell interactions, with implications for inflammatory skin disorders and neuroinflammatory conditions. Key signaling mechanisms involve NF-kappaB inhibition, cAMP pathways, and purinergic receptor activation.
Analysis of his publication record reveals consistent focus on molecular neuroimmunology, with recent work emphasizing IL-6 signaling in Th17 immunity and neuropeptide-endothelial crosstalk. His studies integrate cellular immunology, molecular signaling, and translational approaches to dissect neuroimmune interfaces in cutaneous and neural systems.
Dr. Wagner maintains leadership roles and ownership in Sveikatal, Inc., reflecting industry engagement in biotechnology. His research program within the Brain and Mind Research Institute fosters collaborations across immunology, neuroscience, and dermatology to advance therapeutic strategies for neuroinflammatory diseases.
