John Hunt

John Hunt is a Professor of Biological Sciences at Columbia University, where he leads the Hunt Lab. His research focuses on the structural biology of transmembrane transport, protein folding, and molecular mechanisms of biochemical processes, utilizing techniques such as X-ray crystallography, cryo-EM, and protein spectroscopy.

• Email: jfh21@columbia.edu
• Lab Website: Hunt Lab

Research Interests:

• Structural and thermodynamic mechanisms of protein-mediated transmembrane transport
• Protein structure-dynamics relationships
• Development of artificial protein machines
• ABC transporter systems and translation factors
• Enzymatic mechanisms in membrane insertion/retraction cycles

Publications highlight his work on:

• Structural studies of ABC transporters and CFTR
• Mechanistic insights into SecA ATPase and ribosomal processes
• Protein crystallization optimization techniques
• Roles of ABCF proteins in antibiotic resistance and immune response

Labs & Teams: The Hunt Lab collaborates with interdisciplinary teams, integrating structural biology, biophysics, and computational methods to explore complex biochemical systems.