Jay D. Horton

Jay D. Horton is a faculty member at the University of Texas Southwestern Medical Center, School of Medicine, Department of Molecular Genetics. His research focuses on transcriptional regulators of lipid metabolism, particularly the roles of SREBPs and PCSK9 in cholesterol and fatty acid homeostasis. His lab investigates molecular mediators of hepatic steatosis in diseases like diabetes and obesity, alongside PCSK9's function in LDL cholesterol regulation.

• University of Iowa: B.S. (1984), M.D. (1988)
• UT Southwestern Medical Center: Internal Medicine Residency (1988-1991), Gastroenterology Fellowship (1991-1994)
• Howard Hughes Medical Institute: Postdoctoral Fellowship in Molecular Genetics

His work bridges clinical digestive diseases with molecular mechanisms, emphasizing translational applications for metabolic disorders. Publications highlight RNA interference therapies, lipid metabolic pathways, and cross-disciplinary collaborations in cardiovascular and liver research.