Guosheng Liang

Dr. Guosheng Liang is a Professor in the Department of Molecular Genetics and Center for Human Nutrition at the University of Texas Southwestern Medical Center. He completed his BS in Biochemistry at Peking University (1991) and PhD in Biochemistry at The Ohio State University (1997). After postdoctoral training in Drs. Michael Brown and Joseph Goldstein's lab at UT Southwestern, he worked as a Senior Scientist at Eli Lilly before joining UT Southwestern as an Assistant Professor in 2005.

His research focuses on lipid and cholesterol metabolism, particularly the role of sterol regulatory element-binding proteins (SREBP) in metabolic regulation. Key areas include SREBP signaling pathways, cholesterol homeostasis, intestinal lipid processing, and the interplay between metabolic pathways and inflammation. Collaborations with renowned scientists like Drs. Brown and Goldstein (Nobel laureates in cholesterol research) highlight his contributions to understanding molecular mechanisms underlying metabolic disorders.

Dr. Liang's recent work explores postprandial metabolic responses, ER stress-induced metabolic changes, and therapeutic interventions targeting SREBP pathways. His studies span liver, intestinal, and cartilage biology, with implications for atherosclerosis, steatohepatitis, and diabetes. Despite extensive publication output, no specific awards or grants are explicitly listed in the provided text.

Lab collaborations involve the Department of Molecular Genetics and Center for Human Nutrition, focusing on translational research linking basic molecular mechanisms to clinical metabolic conditions. Ongoing work includes investigating novel SREBP inhibitors and metabolic signaling pathways in health and disease.