James J Manfredi

James J. Manfredi is a Professor in Oncological Sciences and Cell, Developmental & Regenerative Biology at the Icahn School of Medicine at Mount Sinai. His research focuses on elucidating molecular mechanisms governing p53's role in tumor suppression, transcriptional regulation, apoptosis, and cell cycle checkpoints following DNA damage. Key interests include post-translational modifications of p53, interactions with co-activators like p300/CBP, and the interplay between p53 and Sp/KLF family members regulating cell fate decisions.

Education: MS and PhD in Molecular Biology from Albert Einstein College of Medicine. Office locations include the Icahn (East) Building in New York City.

Research highlights include studying the C-terminal basic region of p53, p53-dependent transcriptional repression of mitotic regulators (e.g., Cdc25C, Survivin), and novel roles of Mdm2 in checkpoint regulation. His work explores how p53 mutations contribute to cancer progression and therapeutic resistance.

Publications include breakthrough studies in EMBO Reports, Cancer Discovery, and Nature Cancer, though specific years are not provided here.