معرفی
Igor I. Slukvin is a Professor in the Department of Pathology and Laboratory Medicine at the University of Wisconsin–Madison. He holds joint appointments in Cell & Regenerative Biology and is an affiliate scientist at the Wisconsin National Primate Center. His research focuses on hematopoietic and endothelial development from human pluripotent stem cells (PSCs), aiming to advance bone marrow transplantation, transfusion medicine, and cancer immunotherapy.
Slukvin’s work has identified cellular pathways for generating hematopoietic progenitors, endothelial cells, and mesenchymal stromal cells from PSCs. He pioneered transgene-free iPSC reprogramming and developed protocols for scalable blood cell production. His lab’s articles highlight innovations in immunotherapy (e.g., anti-GD2 CAR macrophages), preclinical NHP models, and genetic engineering to combat diseases like AIDS and leukemia.
His research employs genomics, proteomics, and bioinformatics to dissect molecular mechanisms in blood cell specification. Current projects include creating definitive lympho-myeloid hematopoiesis models, iPSC-based bone marrow therapies, and cancer immunotherapies. The lab’s comparative analysis of fetal and PSC-derived blood cells informs drug discovery and therapeutic strategies.
