Helen Mott

Helen Mott is a Professor in the Department of Biochemistry at the University of Cambridge. Her research focuses on understanding the structure, dynamics, and membrane interactions of small GTPases and their effector proteins. These proteins are critical in processes like cell cycle regulation and vesicle trafficking, with implications for cancer research.

Her group investigates how small GTPases recognize effectors, using structural biology (e.g., NMR, cryo-EM) and develops stapled peptides to inhibit their interactions. Key projects include studying Ral GTPases and Cdc42 signaling in cancer contexts.

Publications highlight work on effector complex structures, membrane dynamics, and therapeutic peptide design. The Mott and Owen Group collaborates on structural and functional studies, contributing to both basic science and potential clinical applications.