Brennwald P

Brennwald P is a Professor at the University of North Carolina at Chapel Hill School of Medicine, Department of Cell Biology and Physiology. His research focuses on molecular mechanisms of exocytosis, vesicle trafficking, and GTPase signaling in cellular and neuronal contexts.

Key research areas include:

• Structural and functional analysis of exocyst complex regulation
• Role of Rab GTPases and SNARE proteins in membrane dynamics
• Neuronal trafficking mechanisms in schizophrenia-linked pathways
• Development of cryo-EM methodologies for protein complex visualization
• Training program innovations for biomedical career preparation

Recent work (2020–2025) reveals trends in:

• Allosteric activation of tethering complexes
• Phosphoinositide-sensitive trafficking regulation
• Structural transitions in exocytic machinery
• Multi-user facility cryo-EM protocols
• Quantitative proteomics of vesicle populations