معرفی
Guy Tanentzapf is a Professor in the Department of Cellular & Physiological Sciences at the University of British Columbia's Faculty of Medicine. He holds a PhD in Zoology and a B.Sc. (Honours) in Molecular Biology and Molecular Genetics from the University of Toronto, and completed postdoctoral training at the Gurdon Institute, University of Cambridge.
Research Focus: His lab investigates how cell junctions and extracellular matrix (ECM) interactions regulate tissue development and stem cell behavior. Key areas include integrin signaling, gap junction communication, calcium signaling networks, and ECM organization in hematopoiesis, melanoblast migration, and spermatogenesis.
Methodology: The lab employs multidisciplinary approaches combining Drosophila and mammalian models with genetics, quantitative imaging, biochemistry, and systems biology to uncover regulatory mechanisms of cell adhesion molecules.
Lab Highlights:
- Revealed integrin's role in hematopoietic cell signaling (2020)
- Discovered gap junction-mediated calcium networks controlling blood progenitors (2021)
- Identified somatic gene networks essential for spermatogenesis (2017)
- Established mechanical force transmission through cell-ECM adhesion (2016)
Lab Website: www.tanentzapf-lab.com
