معرفی
David Calderwood is a Professor of Pharmacology and Cell Biology at Yale School of Medicine, where he also serves as co-Director of Graduate Studies for the Pharmacology Graduate Program. He holds primary appointments in the Department of Pharmacology and secondary appointments in Cell Biology, with additional affiliations across multiple interdisciplinary programs including Cancer Signaling Networks, Vascular Biology and Therapeutics, and Yale Cancer Center.
Dr. Calderwood received his PhD from the University of Manchester in 1996. His research program focuses on molecular mechanisms of cell adhesion, particularly integrin receptor signaling and cytoskeletal dynamics. Key research interests include:
- Integrin activation mechanisms through talin and kindlin interactions
- Mechanical force transmission in cell-ECM adhesions
- Cytoskeletal regulation of cell migration and adhesion
- Structural basis of integrin-mediated signaling complexes
His recent publications demonstrate a strong focus on mechanobiology and advanced imaging techniques, with recurring themes of integrin trafficking, cytoskeletal tension sensing, and molecular basis of adhesion complex assembly. The work frequently bridges structural biology with cellular biophysics, employing techniques from molecular modeling to live-cell imaging.
Dr. Calderwood has received significant research funding, including a $1,390,200 NIH grant with Titus Boggon (2009) and a $1,356,968 NIGMS grant (2009). As co-Director of Graduate Studies, he oversees doctoral training in pharmacology while maintaining an active research laboratory investigating fundamental cell adhesion mechanisms relevant to cancer, immunology, and vascular biology.
