Gary B. Huffnagle

Gary B. Huffnagle is a Professor of Molecular, Cellular, and Developmental Biology at the University of Michigan, with joint appointments in the Medical School's Departments of Internal Medicine and Microbiology & Immunology, and the Mary H. Weiser Food Allergy Center. He holds the Nina and Jerry D Luptak Professorship in Food Allergy. His research focuses on mucosal immunity, microbiome interactions, and their roles in food allergies, respiratory diseases, and infectious processes. Key affiliations include the Huffnagle Lab and collaborative work across multiple interdisciplinary centers.

Education: Ph.D., 1990 from University of Texas Southwestern Medical Center.

Research emphasizes three core areas: 1) microbiota-driven immunological tolerance mechanisms in food allergies, 2) microbial ecology of Candida albicans and Lactobacillus johnsonii in mucosal surfaces, and 3) non-aeruginosa Pseudomonas species in respiratory inflammation. Recent work highlights microbiome shifts in chronic lung diseases and critical illness.

Publications span over 20 years, with recent focus on microbiome contributions to COPD, pulmonary fibrosis, and asthma exacerbations. His work integrates computational biology, microbial genomics, and immunological approaches.