معرفی
G. Angus McQuibban is a Professor in the Department of Biochemistry at the University of Toronto. After completing his undergraduate degree and M.Sc. at the University of Toronto, he earned his Ph.D. in Biochemistry and Molecular Biology at the University of British Columbia (Vancouver). His postdoctoral work at the MRC Laboratory of Molecular Biology in Cambridge focused on Rhomboid proteases. Since establishing his lab in 2005, he has investigated mitochondrial quality control pathways, particularly their role in neurodegenerative diseases like Parkinson’s disease.
His research explores how proteases regulate mitophagy (mitochondrial autophagy) and how dysregulation contributes to disease etiology. The lab combines basic science with translational studies and small molecule screening to identify novel therapeutics. McQuibban has received significant funding for drug discovery in neurodegenerative diseases via AI-driven approaches.
- Key Research Areas: Mitochondrial dysfunction, proteostasis, neurodegeneration
- Recent Trends: Focus on protease-mediated signaling, mitophagy mechanisms, and computational biology applications
He teaches advanced courses in biochemistry, including Mitochondrial Quality Control in Health and Disease and Organelles and Cell Function, and is involved in graduate and undergraduate research training programs.
