جستجوی استاد راهنمای دانشگاهی

Wing Lam is an Associate Research Scientist in the Department of Pharmacology at the Yale School of Medicine. He holds a BSc in Molecular Biology and a PhD in Biochemical Pharmacology from City University of Hong Kong, followed by postdoctoral training at Yale. His research focuses on developing traditional Chinese medicine (TCM) formulations as adjuvants for cancer therapy, notably YIV-906, which enhances chemotherapy efficacy and mitigates intestinal toxicity. Lam also pioneered the STAR database for herbal drug discovery and the Mechanism-Based Quality Control (MBQC) platform for botanical drug standardization. Education: BSc (Hons) Molecular Biology, City University of Hong Kong, 1995 PhD Biochemical Pharmacology, City University of Hong Kong, 1999 Postdoc, Pharmacology, Yale University, 1999-2002 His research interests span cancer pharmacology, TCM modernization, and mitochondrial toxicity mechanisms. Key projects include YIV-906’s role in enhancing anti-PD1 and CAR T-cell therapies, developing L-nucleoside analogs like troxacitabine, and investigating tylophorine analogs’ antitumor effects. Lam has co-chaired sessions at multiple Consortium for Globalization of Chinese Medicine (CGCM) meetings and contributed to patents on herbal drug formulations and quality control methods. Recent work explores YIV-906’s potential for inflammatory bowel disease (IBD) and phase II clinical trials for colon and liver cancers. Lam’s publications highlight synergistic drug interactions, mitochondrial DNA depletion mechanisms, and TCM’s evidence-based application in chronic diseases. His grants include studies on PHY906 as an adjuvant in rectal cancer therapy and collaborations with Yiviva, Inc. He maintains active roles in editorial boards, including a special issue on herbal drug quality control in Frontiers in Pharmacology . Lam’s lab is embedded within Dr. Yung-Chi Cheng’s group, focusing on translational pharmacology and botanical drug innovation.

• Pharmacology
• Traditional Chinese Medicine
• Cancer Therapy
• +۷ مورد دیگر

Prof. Dr. Christian Erik Pohl is an Adjunct Professor at ETH Zurich's Department of Environmental Systems Science and Head of the Institute for Environmental Decisions (IED) and the Transdisciplinarity Lab (TdLab). His research focuses on advancing transdisciplinary approaches to address complex environmental and societal challenges, emphasizing sustainable development. He holds a doctorate and habilitation in environmental science from the University of Bern. Key roles include membership in the Swiss National Science Foundation’s NRP 82 steering committee and the scientific advisory board of td-net. His contributions include seminal works like Principles for Designing Transdisciplinary Research and the Handbook of Transdisciplinary Research , fostering global collaboration in sustainability science. Awards include the KITE Award (2020) for teaching excellence and the Swiss-academies award (2015). He co-leads the TdLab, advancing methods for integrating academic and societal knowledge to tackle issues like biodiversity, water management, and climate change. His courses include 'Tackling Environmental Problems' and 'Transdisciplinary Research: Challenges of Interdisciplinarity and Stakeholder Engagement,' reflecting his commitment to education in sustainability science.

• Environmental Science
• Sustainability Science
• Transdisciplinary Research
• +۳ مورد دیگر

James Shorter is a Professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania. He is affiliated with multiple prestigious institutes, including the Institute on Aging (IOA), the Institute for Translational Medicine and Therapeutics (ITMAT), the Penn Center for AIDS Research (CFAR), the Chemistry-Biology Interface (CBI), and the Penn Institute for RNA Innovation. He mentors several training programs such as the Penn Summer Undergraduate Internship Program (SUIP), PennPREP, and the Translational Research Immersion Program (TRIP), and serves as a Primary Trainer at the Center for Neurodegenerative Research (CNDR). Ph.D. in Cell Biology, University of London, 2000 M.A. in Biology, University of Oxford, 1995 Dr. Shorter’s research focuses on protein homeostasis, particularly the mechanisms of protein disaggregation and the role of prion-like domains in neurodegenerative diseases such as ALS, Alzheimer’s, Parkinson’s, and frontotemporal lobar degeneration. His lab investigates the Hsp104 disaggregase from yeast and has engineered variants to combat human proteinopathies. They also identified the mammalian disaggregase system (Hsp110/Hsp70/Hsp40) and explore how small molecules and nuclear import receptors can reverse pathological phase transitions of RNA-binding proteins like TDP-43 and FUS. His work bridges structural biology, genetics, and translational neuroscience. His recent publications highlight trends in targeting TDP-43 and FUS proteinopathies, engineering Hsp104 for selective detoxification, understanding mitochondrial disaggregases like Skd3, and modulating phase transitions with nuclear import receptors. His research spans from fundamental mechanisms of protein folding to therapeutic development for neurodegenerative diseases. Faculty Member, Institute on Aging (IOA) Faculty Member, Institute for Translational Medicine and Therapeutics (ITMAT) Mentor, Penn Summer Undergraduate Internship Program (SUIP) Primary Trainer, Center for Neurodegenerative Research (CNDR) Faculty Member, Penn Center for AIDS Research (CFAR) Member, Penn Institute for RNA Innovation Mentor, Translational Research Immersion Program (TRIP) Dr. Shorter advises numerous graduate students and postdoctoral researchers through the Biochemistry and Molecular Biophysics, Pharmacology, Neuroscience, and Cell and Molecular Biology graduate groups. His lab receives funding from NIH and other sources to support research on protein disaggregation, phase separation, and neurodegenerative disease mechanisms. He has trained many scientists now active in academia and biotech. His lab, located in Stellar-Chance Laboratories, operates at the intersection of biochemistry, cell biology, and translational medicine, with active projects on Hsp104 engineering, mitochondrial proteostasis, and the role of RNA-binding proteins in disease. The lab collaborates widely across Penn and with international partners to advance understanding and treatment of protein misfolding disorders.

• Protein Folding and Proteostasis
• Neurodegenerative Diseases
• Prion and Amyloid Biology
• +۷ مورد دیگر

Suliana Manley is a Full Professor at the École Polytechnique Fédérale de Lausanne (EPFL) , affiliated with the School of Basic Sciences and the Laboratory of Experimental Biophysics . She also holds teaching and research roles in EPFL's School of Life Sciences and Swiss Plasma Center , focusing on interdisciplinary biophysical studies. Education : PhD in Physics (2004), Harvard University Bachelor's in Physics & Mathematics (1997), Rice University Manley's research centers on super-resolution fluorescence imaging , single-molecule tracking , and quantitative biophysics . Key themes include: Understanding protein assembly dynamics at cellular membranes Elucidating viral assembly mechanisms (e.g., HIV-Gag) Developing 3D imaging algorithms and high-density data reconstruction tools like PALMsiever and FALCON Quantifying nanoscale organization in systems like telomeres and centrioles Her work bridges optical physics , computational image analysis , and cellular biology , with notable Nature and PNAS publications. Collaborations span bioengineering , genetics , and medical research . Scientific Awards : Featured in Nature Methods Research Highlights (3x) Very Important Paper and Cover Article (ChemBioChem, 2012) Postdoctoral Fellow, NIH and MIT Advising & Collaborations : Current PhD students in biophysics, cellular biology, and bioengineering Former students: Anna Archetti, Aleksandr Benke, Andrea Callegari, and others Co-founder of tools for high-density super-resolution microscopy and live-cell imaging Labs & Teams : Leads the Laboratory of Experimental Biophysics at EPFL, integrating physics-based methods into biological questions. The lab focuses on quantitative imaging , computational modeling , and software development for nanoscale analysis.

• Super-resolution Microscopy
• Single-molecule Biophysics
• Protein Assembly
• +۵ مورد دیگر

Professor Sabine Dittmann is a leading expert in coastal ecosystem ecology and marine sciences at Flinders University, Australia. As a Professor of Marine Biology in the College of Science and Engineering, her work bridges research and environmental management, focusing on hypersaline estuaries, blue carbon restoration, and invasive species control. She holds a Habilitation in Ecology from the University of Bremen (2001), PhD from the University of Göttingen (1987), and MSc from the same institution (1984). Her research interests include coastal ecosystem health, mangrove and saltmarsh restoration, and decision support frameworks for marine conservation. She has advised government agencies on marine parks, Commonwealth Marine Reserves, and the Coorong ecosystem. Key roles include national president of the Australian Marine Sciences Association (2012–2014), current president of the Royal Society of South Australia, and member of the Australian Antarctic Science Council since 2019. Her recent work emphasizes the global challenges of hypersaline wetland restoration, invasive species impact, and blue carbon methodologies. Over 112 publications span estuarine dynamics, benthic macrofauna, and policy-relevant ecosystem assessments. Projects like the Coorong benthic surveys highlight her commitment to translating science into conservation action.

• Coastal Ecosystem Ecology
• Benthic Community Ecology
• Mangrove and Saltmarsh Ecology
• +۴ مورد دیگر

Miriam Diamond is a Professor at the Department of Earth Sciences and School of the Environment, University of Toronto. She holds cross-appointments in Chemical Engineering, Dalla Lana School of Public Health, and Physical & Environmental Sciences. PhD in Chemical Engineering (University of Toronto, 1990) MSc in Mining Engineering (Queen’s University, 1984) MSc in Zoology (University of Alberta, 1980) Her research focuses on chemical contaminant fate, transport, and exposure in indoor and urban environments, Arctic regions, and Great Lakes systems. She develops mathematical models , passive sampling methods , and policy frameworks to address pollution from flame retardants, phthalates, PFAS, and microplastics. Recent publications highlight microplastic extraction techniques , sleeping children’s exposure , and polymeric flame retardant risks . Key awards include the Royal Society of Canada Fellowship and 2025 President’s Impact Award . She supervises PhD candidates Anna Shalin , Lin Boynton , and others. Her policy contributions include serving on the Canadian Chemical Management Plan Science Committee and co-chairing the Earth Commissioner initiative.

• Environmental Chemistry
• Pollution & Air Quality
• Chemical Contaminants
• +۶ مورد دیگر

Prof. Dr. Ralph Bock serves as Director of Department 3: Organelle Biology, Biotechnology and Molecular Ecophysiology at the Max Planck Institute of Molecular Plant Physiology in Potsdam, Germany, where he also leads the Organelle Biology and Biotechnology research group. Previously, he held positions as C4 Professor for Plant Biochemistry and Biotechnology at the University of Münster (2001-2004) and Group Leader at the Institute of Biology III, University of Freiburg (1996-2001). His academic credentials include: Habilitation: University of Freiburg, 1999 Doctorate: University of Freiburg, 1996 Diploma: University of Halle, 1993 Prof. Bock's research focuses on plant molecular biology with particular emphasis on chloroplast biology, organelle biotechnology, and molecular ecophysiology. His work spans genetic engineering of plastids, photosynthesis research, plant biotechnology applications, and understanding organelle-nucleus communication. He has made significant contributions to developing chloroplast transformation systems and applying them to molecular farming, metabolic engineering, and understanding fundamental processes in plant cell biology. His research has important implications for sustainable agriculture, bioenergy, and pharmaceutical production, particularly through the development of plant-based systems for producing vaccines and therapeutic proteins. Analysis of Prof. Bock's recent publications (2023-2025) reveals a strong focus on chloroplast biology, genetic engineering, and molecular farming applications. His work spans fundamental research on organelle genetics, photosynthesis, and stress responses, as well as applied research on using plant and algal systems for biopharmaceutical production. A notable trend is the increasing use of advanced genetic engineering techniques, including CRISPR-based approaches, to manipulate organelle genomes. His research also shows growing interest in algal systems as alternative expression platforms for molecular farming, particularly red algae like Porphyridium for producing viral antigens and glycoproteins.

• Plant Molecular Biology
• Chloroplast Biology
• Organelle Biotechnology
• +۷ مورد دیگر

Michael J. Ragusa is an Associate Professor of Chemistry at the Department of Chemistry, College of Arts and Sciences, Dartmouth College , specializing in molecular mechanisms of selective autophagy . His research integrates structural biology , biochemical reconstitution , and cell biology to understand how cells degrade toxic components like damaged organelles. Education: B.S. in Chemistry from Siena College, Ph.D. in Biochemistry from Brown University His work focuses on autophagy , particularly the role of Atg proteins in membrane tethering and cargo selection. His lab has published extensively on mitophagy , ALFY , and Atg11 , linking defects in these pathways to cancer , neurodegeneration , and infectious diseases . Recent studies highlight mechanisms of vesicle clustering and dimerization-dependent membrane interactions . Dr. Ragusa teaches courses such as CHEM 5: General Chemistry , CHEM 42: Biological Chemistry II , and CHEM 95.05: Protein Crystallography . His lab employs techniques like X-ray crystallography , NMR spectroscopy , and membrane reconstitution to dissect protein-lipid interactions.

• Structural Biology
• Biochemical Reconstitution
• Autophagy
• +۵ مورد دیگر

Owen Skinner is an Assistant Professor in the Department of Chemistry and Chemical Biology at Northeastern University, affiliated with the Barnett Institute of Chemical and Biological Analysis. He leads the Skinner Lab, which specializes in high-resolution mass spectrometry to study protein-metabolite interactions in health and disease. Skinner earned his Ph.D. from Northwestern University and conducted postdoctoral research at Massachusetts General Hospital. His research focuses on thiol redox regulation, vitamin cofactor metabolism, and oxidative phosphorylation dynamics. Education: Ph.D. in Chemistry (Northwestern University), Postdoctoral Fellowship in Analytical Chemistry (Massachusetts General Hospital). Research interests include proteomics, metabolomics, mitochondrial dysfunction, and metabolic signaling. The lab actively recruits graduate students, undergraduates, and postdoctoral researchers across Northeastern's scientific community. Affiliations: Barnett Institute, College of Science Lab Members: PhD students Yifan Liu, Michael Xiao, Angela Rojas-Merchan; Undergraduates Helena Rittenhouse, Ridha Shah; High School collaborator Helen Loango Techniques: Native mass spectrometry, proteomics, metabolomics, redox biology Publications span mitochondrial metabolism, metabolic biomarkers in septic shock, and enzyme engineering. The lab emphasizes interdisciplinary collaboration and supports students through Northeastern's experiential learning programs.

• Mass Spectrometry
• Proteomics
• Metabolomics
• +۶ مورد دیگر

Dr. Andrew Bassett serves as Head of the Cellular and Gene Editing Research group at the Wellcome Sanger Institute, where he develops cutting-edge genome engineering techniques using human pluripotent stem cells to investigate neurodegenerative diseases including Alzheimer's and Parkinson's. His work focuses on scaling genetic screening approaches and improving CRISPR specificity for modeling complex disease mechanisms. His academic training includes: PhD at the MRC Laboratory of Molecular Biology (MRC-LMB) with Andrew Travers on chromatin remodelling in heterochromatin formation Postdoctoral research with David Baulcombe at the University of Cambridge studying small RNA roles in chromatin modification Additional postdoctoral work with Chris Ponting at the MRC Functional Genomics Unit (MRC-FGU) in Oxford, where he pioneered CRISPR applications in Drosophila Bassett's research program centers on developing advanced genome engineering methodologies for precise modulation of gene expression networks during development and neurodegeneration. His group specializes in creating complex editing events (SNPs, paired knockouts, enhancer perturbations) within iPSC-derived models, with particular emphasis on epigenetic regulation and transcriptional control. Current projects integrate single-cell 'omics and phenotypic assays to decode genetic causes of neurodegenerative disorders through the OpenTargets consortium. Analysis of his 15 most recent publications reveals dominant trends in CRISPR technology development (35%), neurodegenerative disease modeling (30%), and single-cell functional genomics (25%). His work consistently bridges methodological innovation with disease mechanism studies, increasingly incorporating multi-omics approaches and expanding into cancer immunology and infectious disease applications since 2022. As group leader, Bassett mentors postdoctoral researchers and PhD students while securing major funding for genome engineering initiatives. His team operates within the Sanger Institute's Cellular Operations division and maintains critical partnerships with the OpenTargets consortium for therapeutic target validation. The laboratory specializes in high-throughput screening platforms using iPSC-derived neural and microglial models, with recent methodological advances including scSNV-seq and ONE-STEP tagging systems that significantly enhance precision genome editing capabilities.

• Genome Engineering
• Neurodegenerative Diseases
• Stem Cell Research
• +۵ مورد دیگر

Alexander Stelzleni is a Professor and Graduate Coordinator in the Department of Animal and Dairy Science at the University of Georgia's College of Agricultural & Environmental Sciences. He has been with the University of Georgia since July 2007, progressing from Assistant Professor to Associate Professor in 2013, and ultimately to Professor in 2020. As Graduate Program Coordinator since January 2021, he oversees both the Animal and Dairy Science (ADSC) and Regenerative Bioscience (REBI) graduate programs. Dr. Stelzleni's research program maintains two central foci: (1) the influence of production and management on meat quality and yield with emphasis on southeastern and subtropical beef finishing systems, and (2) further processing to improve quality and safety of red meat and poultry. His lab has been particularly active in studying heat stress mitigation in Southeastern US beef finishing systems, sous vide as a consistent cookery method, further processing of poultry myopathies, and safety of low-thermal meat products. His scholarly work reflects strong expertise in meat science, with recent publications focusing on nicotinamide riboside effects, National Beef Quality Audits, dairy-beef crossbreeding, poultry myopathies, sous vide techniques, and high-pressure processing for pathogen control. The Stelzleni Lab has presented numerous studies at the Reciprocal Meat Conference in recent years, demonstrating consistent productivity and relevance to industry challenges. Student Career Success Influencer Award (2024) Multiple UGA Career Center Awards (2019, 2016, 2015, 2014, 2012) Larry Benyshek Excellence in Teaching Award (2016) ADSC 3650 recognized as top 5 college courses at UGA As an advisor, Dr. Stelzleni has mentored numerous graduate students including Clint Lee (MS thesis on heat stress mitigation), Cameron Catrett (MS 2024), and M. Junaid Nawaz (PhD student). His lab actively involves undergraduates in research and meat judging competitions, with students regularly presenting at professional conferences and winning awards in Iron Chef contests and meat judging events. Dr. Stelzleni directs the Meat Science Technology Center where his team investigates methods to improve meat quality, yield, shelf-life, and safety. The lab maintains strong industry connections with commodity groups, meat processors, and stakeholders to address current challenges in meat production and processing.

• Meat Science
• Muscle Biology
• Beef Production
• +۷ مورد دیگر

Dr. Wael M. Rabeh is an Associate Professor of Chemistry at New York University Abu Dhabi (NYUAD), affiliated with the Division of Science. He holds a PhD in Biochemistry from the University of Oklahoma and conducted postdoctoral research at the Structural Genomic Consortium (University of Toronto) and McGill University. His research focuses on protein structure-function relationships, particularly in disease-relevant proteins such as CFTR (cystic fibrosis transmembrane conductance regulator) and human Hexokinase 2, leveraging X-ray crystallography and biophysical techniques. Key areas include cystic fibrosis mechanisms, cancer metabolism, drug discovery, and bioluminescence. Dr. Rabeh’s work has contributed to understanding CFTR misfolding and functional correction, as well as the role of Hexokinase 2 in tumor growth. His lab collaborates internationally (e.g., with McGill University) and has secured funding from institutions like Al Jalila Foundation, Terry Fox Research Foundation, and NYUAD. He teaches courses in biochemistry and structural biology, emphasizing hands-on experimental approaches. Notable research highlights include the discovery of a dual-step correction mechanism for the ∆F508 CFTR mutation and structural studies of antiviral drugs like Tamiflu. His lab’s bioluminescence research aims to elucidate color-producing mechanisms in luciferases. Dr. Rabeh actively contributes to structural biology education through innovative laboratory curricula and public engagement.

• Protein Structures
• Enzymology
• Structural Biology
• +۶ مورد دیگر

Professor Stephan A. Sieber is a leading researcher in bioorganic chemistry at the Technical University of Munich (TUM), where he holds the Chair of Organic Chemistry II within the TUM School of Natural Sciences. His research program focuses on developing new drugs against multidrug-resistant bacteria through a multi-disciplinary approach that integrates synthetic chemistry, functional proteomics, microbiology, and protein biochemistry. His laboratory has made significant contributions to identifying unprecedented antibacterial targets beyond the scope of current antibiotics and exploiting these for chemical manipulation. Recent work has increasingly incorporated machine learning approaches to accelerate antibiotic discovery, with notable publications on AI-guided pipelines, drug-target interaction prediction, and high-throughput screening optimization. Sieber's research has resulted in the discovery of new active substances, some of which are currently being optimized for medical applications. His group's publications reveal a strong focus on chemical proteome mining, natural product mode of action studies, and novel antibacterial target identification. The lab has published extensively in top journals including Nature Chemistry, Nature Communications, and ACS Central Science. Inhoffen Medal (2024) Max Bergmann Medal (2023) ERC Advanced Grant (2023) Merck Future Insight Prize (2020) Klaus Grohe Prize (2020) ERC Consolidator Grant (2016) Professor Sieber leads an active research group that maintains a strong presence in the scientific community through regular publications, conference presentations, and collaborations. His laboratory website and BlueSky presence (@sieberlab.bsky.social) demonstrate ongoing research activities and engagement with the broader scientific community. He has successfully secured significant research funding including multiple ERC grants that have supported his innovative work in antibiotic discovery.

• Bioorganic Chemistry
• Antibiotic Development
• Chemical Proteomics
• +۵ مورد دیگر

Guillaume Chanfreau is a Professor in the Department of Chemistry and Biochemistry within the College of Letters and Science at the University of California Los Angeles (UCLA). His research focuses on fundamental mechanisms of RNA metabolism, with particular emphasis on RNA splicing, decay pathways, and ribonuclease functions. His work spans molecular biology, biochemistry, and genetics, utilizing yeast as a primary model organism to investigate conserved RNA processing mechanisms. Professor Chanfreau's research interests center on understanding how RNA processing pathways regulate gene expression. His work examines transcription termination, RNA splicing fidelity, RNA decay mechanisms, and the role of ribonucleases in cellular RNA homeostasis. He investigates how these processes are interconnected and how they respond to cellular stress conditions. His laboratory has made significant contributions to understanding how RNA quality control mechanisms prevent the accumulation of aberrant transcripts and maintain cellular health. Analysis of Chanfreau's recent publications (2020-2025) reveals a strong focus on RNA splicing mechanisms, RNA decay pathways, and ribonuclease functions. His work frequently employs yeast genetics combined with advanced RNA sequencing techniques. A notable trend is the increasing use of long-read sequencing technologies to analyze RNA isoforms and decay intermediates. His research consistently bridges fundamental molecular mechanisms with potential implications for understanding human diseases related to RNA processing defects. Professor Chanfreau has been continuously funded by the National Institutes of Health, with his current grant R35GM130370 (2019-2023) titled 'The Control of Gene Expression by Eukaryotic Ribonucleases' and previous long-term funding through R01GM061518 (2000-2019). His research program has supported numerous graduate students and postdoctoral researchers who have contributed to his extensive publication record spanning over two decades.

• RNA metabolism
• RNA splicing
• RNA decay pathways
• +۵ مورد دیگر

Dr. Angela Poole is an Assistant Professor of Molecular Nutrition in the Division of Nutritional Sciences at Cornell University's College of Human Ecology. She leads a research group focused on precision nutrition, investigating interactions between host genetics, dietary intake, and gut/oral microbiomes to prevent metabolic diseases. Education & Background Ph.D. in Genome Sciences, University of Washington Postdoctoral research at Dr. Ruth Ley's laboratory B.S. in Engineering and Applied Science, Caltech Research Focus Her interdisciplinary work combines genetics, microbiology, and nutrition to develop personalized dietary interventions. Key areas include: Optimizing dietary fiber for diabetes prevention Oral biofilm pathogenesis Host-microbiome-diet interactions in metabolic disorders Publication Trends Her 15 most recent publications (2014-2025) demonstrate consistent focus on microbiome dynamics, genetic influences on nutrition, and metabolic health. Recent work emphasizes oral/gut microbiome responses to dietary components like resistant starch and salivary amylase. Research Group Leads an active lab developing systems biology approaches for precision nutrition applications.

• Precision Nutrition
• Gut Microbiota
• Host-Microbe Interactions
• +۴ مورد دیگر