Emmanuel Lemichez

Emmanuel Lemichez is a prominent researcher and Head of Structure at the Institut Pasteur, affiliated with the Mouse Genetics, Immunity and Infections unit and the Ultrastructural BioImaging department in Paris, France. He leads a dynamic research team investigating bacterial protein toxins and their impact on host-pathogen interactions, cellular signaling, and disease pathogenesis.

His research focuses on the molecular mechanisms of bacterial toxins, particularly from Clostridium botulinum, Staphylococcus aureus, and uropathogenic Escherichia coli. Key areas include the action of CNF1 toxin on Rho GTPases, endothelial barrier disruption via transcellular tunnels, and the role of toxin-producing bacteria in colorectal cancer development. His work bridges fundamental cell biology with translational applications, including the development of detection methods and antitoxin countermeasures within the European consortium EuroBioTox.

The recent publications reflect a strong trend in understanding how bacterial toxins manipulate host cell architecture, signaling pathways, and epigenetic regulation. Themes include membrane dynamics, ubiquitylation, mechanotransduction, and microbiome-cancer interactions, published in high-impact journals such as Nature Communications, eLife, and Gut Microbes.

• Principal Investigator, Detection and countermeasures against bacterial toxins
• Principal Investigator, Chronic carriage of CNF1-producing bacteria in the gut and development of colorectal cancer
• Principal Investigator, Endothelium disruption by toxin-induced transcellular tunnels

He supervises a diverse group of researchers, including PhD students and postdoctoral fellows, fostering a collaborative and interdisciplinary environment. His lab is actively engaged in both basic and applied research, contributing significantly to the fields of microbiology, infection biology, and cellular pathogenesis.