معرفی
Elisa Gomez Perdiguero is a Permanent Researcher at the Institut Pasteur in Paris, affiliated with the Membrane, Cytoskeleton and Cell Division unit. She leads the research group focused on the development, maintenance, and functions of tissue-resident macrophages, with a particular emphasis on their embryonic origins and roles in homeostasis and tissue repair. Her work bridges immunology, developmental biology, and cell biology, and she is the Principal Investigator of the ERC-funded project 'ResidentMacroPhage'.
Her research primarily investigates the role of yolk sac-derived erythro-myeloid progenitors (EMPs) in generating tissue-resident macrophages such as microglia, Kupffer cells, and Langerhans cells, which self-maintain independently of hematopoietic stem cells (HSCs). She uses mouse and zebrafish models, along with advanced techniques like flow cytometry, lineage tracing, and transgenesis, to explore the ontogeny and functional specialization of macrophages during development and in response to injury.
The trends in her recent publications highlight a consistent focus on developmental hematopoiesis, macrophage heterogeneity, and the interplay between macrophages and endothelial cells. Her work has demonstrated the critical role of early macrophage waves in shaping immune and vascular development, with implications for regenerative medicine and inflammatory diseases.
Scientific awards and recognitions include:
- ERC-2016-StG _ResidentMacroPhage – Development, Maintenance and Functions of Resident Macrophages
She has actively mentored numerous PhD students and postdoctoral researchers, including Lorea Iturri, Rebeca Ponce Landete, Alina Sommer, and others. Her lab has received funding from major programs such as LabEx Revive and the IP Stem Cell Initiative, supporting research in regenerative biology and medicine. She is currently recruiting for fully funded postdoctoral and PhD fellowships.
Elisa Gomez Perdiguero's team collaborates within transversal programs such as 'Mother and Child Health' and participates in the broader Institut Pasteur ecosystem focused on precision medicine and open science.
