معرفی
Edward Stites, MD, PhD, is an Associate Professor in the Department of Laboratory Medicine and Pathology at Yale School of Medicine. His interdisciplinary research integrates mathematical modeling, computational biology, and experimental methods to study cancer biology, with a focus on RAS protein signaling networks and precision oncology.
Education:
- BS in Mathematics (University of Kentucky, 1998)
- PhD in Biophysics (University of Virginia, 2008)
- MD (University of Virginia, 2010)
- Clinical Pathology Residency (Washington University School of Medicine, 2015)
- Postdoctoral Fellowship (Translational Genomics Research Institute, 2012)
Dr. Stites leads the Stites Lab, which develops computational models to investigate challenging problems in cancer biology. Their primary research themes include:
- Mathematical modeling of oncogenic signaling pathways (RAS, RAF, GPCR)
- Computational analysis of cancer mutation frequencies and therapeutic vulnerabilities
- Systems biology approaches to identify biomarkers for targeted therapies
- Integrative genomic analyses of tumor evolution and drug resistance
His recent publications demonstrate a consistent focus on RAS pathway biology, spanning mechanistic studies of protein conformations to population-level genomic analyses. Research trends include development of combination therapies, computational mutagenesis techniques, and translational applications in precision oncology.
Scientific Awards:
- NIH Director's New Innovator Award (DP2, 2020)
- DoD Career Development Award (2020)
- American Lung Association Discovery Award (2020)
- Melanoma Research Alliance Young Investigator Award (2018)
- NCI Career Development Award (2017)
- Randy Pausch Scholar Award (2012)
The Stites Lab maintains active collaborations across Yale Cancer Center and receives funding from multiple NIH grants. Current projects focus on developing mathematical frameworks to predict therapeutic responses in RAS-driven cancers and improving cost-effectiveness of precision medicine approaches.
