معرفی
Dr. Zenta Walther is an Associate Professor of Pathology at Yale School of Medicine and former Clinical Director of the Yale New Haven Hospital Tumor Profiling Laboratory. She holds an MD from Cornell University and PhD from Rockefeller University, with residency and fellowship training at Yale. Her clinical expertise spans gastrointestinal/liver pathology and molecular diagnostics of solid tumors.
Her research focuses on precision oncology through molecular characterization of tumors to identify therapeutic targets. Key interests include:
- Genomic alterations in lung, breast, and liver cancers
- Mechanisms of resistance to targeted therapies (e.g., EGFR inhibitors)
- Development of molecular diagnostics for clinical implementation
Her recent publications demonstrate a strong focus on cancer genomics and therapeutic resistance, with recurring themes in EGFR mutation biology, immunotherapy resistance mechanisms, and molecular heterogeneity in solid tumors. Trends indicate extensive use of next-generation sequencing and translational approaches bridging laboratory findings with clinical applications.
As Director of the Molecular Genetic Pathology Fellowship, she oversees trainee education. She co-leads the Yale Precision Medicine Tumor Board and is actively involved in clinical trials investigating resistance mechanisms in lung cancer (NCT identifier not provided). She directs research at the Tumor Profiling Laboratory focusing on genomic analysis of patient specimens.
