معرفی
Anna Wurtz is a Researcher at the Yale School of Medicine, affiliated with the Politi Lab at Yale Cancer Center. Her work focuses on understanding mechanisms of therapeutic resistance in EGFR-mutant lung cancers and optimizing targeted therapies. She collaborates with prominent researchers like Katerina Politi and Scott Gettinger.
Research Interests: Wurtz’s research explores molecular mechanisms driving drug resistance in lung adenocarcinomas, including chromatin remodeling (SWI/SNF complexes), tumor suppressor gene interactions, and immune checkpoint inhibitor resistance. Her studies often combine preclinical models with clinical data to identify actionable biomarkers.
Key Findings: Her work has identified ASCL1’s role in osimertinib tolerance, demonstrated co-occurring tumor suppressor gene alterations’ impact on patient outcomes, and revealed mechanisms of acquired resistance to PD-1 inhibitors. Recent studies highlight chromatin remodeling pathways and HLA class I defects as critical therapeutic targets.
Labs/Teams: She is embedded in the Politi Lab, a leading group in oncogene-driven cancer biology and drug resistance research.
