Xiaofeng Wang

Xiaofeng Wang is an Assistant Professor of Molecular and Systems Biology at Dartmouth College, focusing on cancer epigenetics and chromatin remodeling complexes. His research investigates the roles of SWI/SNF complex mutations in human cancers, particularly ARID1A, and explores therapeutic targets through genetic/chemical screens.

• Department: Molecular and Systems Biology
• Email: Xiaofeng.Wang@dartmouth.edu

Research Interests: The lab studies chromatin remodeling dynamics, SWI/SNF complex assembly, and epigenomic regulation in cancer. Key areas include:

• Mechanistic analysis of SWI/SNF mutations in tumorigenesis
• Enhancer landscape formation and gene regulation
• Signal-dependent chromatin targeting
• Identification of synthetic lethal interactions
• 3D genome architecture prediction
• Therapeutic targeting in malignant rhabdoid tumors

Article Trends: Publications span 2014-2025, emphasizing SWI/SNF complex mutations, enhancer regulation, and computational modeling of chromatin structures. Research bridges molecular biology, epigenetics, and computational genomics.

Laboratory Focus: The team employs biochemical, genomic, and epigenomic assays across model systems to unravel fundamental epigenetic mechanisms driving tumor development, with recent work leveraging machine learning for 3D genome prediction.