معرفی
Cigall Kadoch is an Associate Professor of Pediatric Oncology at Harvard Medical School and Dana-Farber Cancer Institute, with affiliations at the Broad Institute as an Institute Member and Epigenomics Program Co-Director. Her research focuses on chromatin remodeling complexes, particularly the SWI/SNF (BAF) complex, and their roles in cancer and neurodevelopmental disorders. She established her lab at 28, becoming one of the youngest faculty at Harvard Medical School. Her work integrates biochemistry, structural biology, and genomics to understand how chromatin perturbations drive disease and identify therapeutic strategies.
- Education: PhD in Cancer Biology from Stanford University.
- Affiliations: Dana-Farber Cancer Institute, Broad Institute, Harvard Medical School.
Research interests include the structural and functional mechanisms of chromatin remodeling complexes, their mutations in over 25% of human cancers, and development of novel therapies targeting these complexes. Her lab employs multidisciplinary approaches, combining molecular biology, systems biology, and drug discovery.
Awards:
- 2024 Blavatnik National Award Laureate
- 2023 Paul Marks Prize for Cancer Research
- NIH New Innovator Award (2014)
- MIT Technology Review '35 Innovators Under 35' (2015)
- Forbes '30 Under 30' (2014)
Grants and Funding: Major NIH grants, Pew Foundation support, and industry partnerships. Her lab studies therapeutic vulnerabilities in cancers driven by BAF complex mutations, including small cell lung cancer and sarcomas.
Labs/Teams: Kadoch Lab at Dana-Farber, co-leading the Broad Institute’s Epigenomics Program. The lab hosts a team of ~25 researchers focusing on chromatin biology and translational oncology.
