معرفی
Dieter Brömme is a Professor in the Department of Biochemistry & Molecular Biology at the Faculty of Medicine, University of British Columbia (UBC), holding a Tier I Canada Research Chair in Proteases and Diseases. His research focuses on lysosomal cysteine proteases, particularly cathepsins, and their roles in extracellular matrix degradation and disease states such as osteoporosis, arthritis, atherosclerosis, dental diseases, and skin aging.
- Education: MSc (1980), PhD (1983) from Martin Luther University Halle-Wittenberg, D.Sc. (1997) from Friedrich-Schiller-University Jena.
Research Interests: Dr. Brömme's work combines structural biology, enzymology, and translational approaches to target proteases in disease. His lab identified cathepsins K, S, V, F, and W, solved the first cathepsin K structure, and developed Affinity Crystallography to discover natural protease inhibitors. Current efforts center on substrate-specific ectosteric inhibition to avoid side effects in protease-targeted therapies.
Recent Publications: His articles address collagen degradation mechanisms, drug design, and natural product inhibitors from Chinese herbs like Salvia miltiorrhiza. These studies span journals including PNAS, J Clin Invest, and Br J Pharmacol, with interdisciplinary methods ranging from molecular cloning to murine models.
Collaborations: The lab engages internationally, with trainees from multiple continents. Funding comes from NIH, CIHR, and NSERC. Media coverage highlights his work on herbal inhibitors for bone loss (GEN News Highlights, Hindustan Times, Pharmaceutical-Technology).
