Michał Paweł Jewgiński

Michał Paweł Jewgiński is a researcher at the Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Science and Technology, Poland. His work focuses on synthesizing hybrid phosphonodehydropeptides and evaluating their inhibitory activity against cathepsin C, a cysteine protease linked to inflammatory diseases.

Research Interests: His studies span Biochemistry, Medicinal Chemistry, and Organic Chemistry, with a focus on peptidomimetic design, structural analysis of dehydroamino acid-containing peptides, and enzyme inhibition mechanisms. Recent work highlights the role of (Z)-dehydrophenylalanine in inducing ordered conformations and modulating cathepsin C activity.

Publications: Key contributions include

• Hybrid phosphonodehydropeptides (2022)
• Phosphinotripeptidic inhibitors of leucylaminopeptidases (2021)
• Dehydrodipeptide esters as cathepsin C inhibitors (2015)
• Pentapeptides with dehydrophenylalanine residues (2008)
• Dehydrophenylalanine-containing p-nitrophenylanilides (2006)

His research emphasizes structure-activity relationships for protease-targeting therapeutics.