معرفی
Justin S. Miller is a Professor of Chemistry at Hobart and William Smith Colleges (HWS), where he has been a faculty member since 2004. He holds a Ph.D. from the Massachusetts Institute of Technology and completed postdoctoral training at Memorial Sloan-Kettering Cancer Center, with an A.B. from Princeton University. His research is centered in the Department of Chemistry within the School of Arts and Sciences, focusing on the synthesis of bioactive molecules with therapeutic potential.
- Ph.D., Massachusetts Institute of Technology
- Postdoctoral, Memorial Sloan-Kettering Cancer Center
- A.B., Princeton University
Dr. Miller's research interests lie in bioorganic and synthetic organic chemistry, particularly in solid-phase synthesis of cyclic depsipeptides that act as histone deacetylase (HDAC) inhibitors—compounds with anticancer activity. His lab develops novel methodologies combining solid-phase synthesis and chemoselective ligation to access complex peptidic structures, including natural products like Spiruchostatin A and FK228. These techniques enable the synthesis of cysteine-containing molecules and have broad applications in drug discovery.
His recent publications reflect a dual focus on synthetic methodology and chemical education. Trends show a consistent commitment to undergraduate research, with students frequently co-authoring publications. The work spans organic synthesis, medicinal chemistry, and pedagogical innovation in chemistry education.
Scientific awards and grants highlight his research impact:
- Camille and Henry Dreyfus Start-up Award
- Research Corporation Cottrell College Science Award
- National Science Foundation (NSF) Grant #1044396
- NIH-AREA Grant #1R15CA152869-01
- NSF MRI Grant #0722178
Dr. Miller is an active mentor, advising undergraduate researchers such as Sarah Lewicki, Lily Walker, and Emily Rundlett. His teaching includes Organic Chemistry I–III and innovative courses like 'Bonding with Food,' reflecting his philosophy of making chemistry accessible and relevant. He has led external grant-funded projects that integrate cancer therapeutics into undergraduate lab curricula. Additionally, he co-created the 'Communicating Chemistry' outreach program, which uses regional cuisine to teach chemical principles, demonstrating a strong commitment to science communication and pedagogy.
His laboratory develops advanced solid-phase resins for peptide synthesis and explores applications in anticancer agent development. The Miller group emphasizes hands-on research training, fostering a collaborative environment where students contribute meaningfully to scientific discovery.
