Scott Miller

Scott Miller is the Sterling Professor of Chemistry and Department Chair at Yale University's Department of Chemistry within the Faculty of Arts and Sciences. He is also affiliated with the Yale Cancer Center as a member of the Developmental Therapeutics Program, demonstrating the translational nature of his research.

Professor Miller's research focuses on the creation of new catalysts for complex molecule synthesis and derivatization, with particular emphasis on peptide-based catalysts for enantioselective reactions. His lab explores the application of asymmetric catalysis principles to regioselectivity, site-selectivity, and chemoselectivity, especially in natural product diversification. The Miller Lab targets molecular functionality ubiquitous in complex natural products to use these materials as scaffolds for new bioactive entity synthesis.

Recent publications reveal significant advances in areas including atropisomerism, enantioselective hydrodifluoroalkylation of alkenes, catalyst-controlled regiodivergent oxidation, and site-selective protein editing. His work bridges fundamental chemical principles with potential biomedical applications through his cancer center affiliation.

Professor Miller maintains an active research program with numerous high-impact publications in leading chemistry journals including Nature Chemistry, Journal of the American Chemical Society, and Nature Chemical Biology. His research demonstrates consistent innovation in catalytic methodology development and application to complex molecular systems.

The Miller Lab employs combinatorial methods for catalyst screening and optimization, drawing mechanistic analogies to enzymes while developing novel peptide-based catalytic platforms. This approach has enabled significant advances in selective synthesis of complex molecules with potential applications in medicinal chemistry and drug discovery.